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Farmacocinética,
Modelagem & Simulação

Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report.

Molecular Pharmaceutics, v. 22, p. 5-27, 2025.

Editorial: Advanced approaches in pediatric clinical pharmacology

Frontiers in Pharmacology, v. 15, 1372290, 2024.

Experiences and initiatives on pharmacokinetic modeling and simulation data analysis: Perspectives from the Brazilian Health Regulatory Agency (ANVISA)

Regulatory Toxicology and Pharmacology, v. 154, 105728, 2024.

PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia.

Frontiers in Pharmacology, v. 14, 1068153, 2023.

Adult and pediatric physiologically based biopharmaceutics model to explain lamotrigine immediate release dissolution and absorption process.

CPT: Pharmacometrics & Systems Pharmacology v. 13, p. 208-221, 2023.

Farmacometria Aplicada ao Desenvolvimento de Medicamentos.

Correlação in vitro – in vivo no desenvolvimento de medicamentos. Marcelo Gomes Davanço, Daniel Rossi de Campos, Leonardo de Souza Teixeira (orgs). 1. ed. Curitiba: Appris, 2023.

Model-informed drug development of gastroretentive release systems for sildenafil citrate.

European Journal of Pharmaceutics and Biopharmaceutics, v. 1, p. 1-10, 2023.

PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia.

Frontiers in Pharmacology, v. 14, p. 1, 2023.

Exploring in vitro solubility of lamotrigine in physiologically mimetic conditions to prospect the in vivo dissolution in pediatric population.

Biopharmaceutics & Drug Disposition, v. 1, p. 1, 2023.

Nanomedicine Ex Machina: Between Model-Informed Development and Artificial Intelligence.

Frontiers in Digital Health, v. 4, p. 1-12, 2022.

Biopredictive tools for the development of injectable drug products.

Expert Opinion on Drug Delivery, v. 19, p. 671-684, 2022.

Pharmacokinetics of amoxicillin in obese and nonobese subjects.

British Journal of Clinical Pharmacology, v. 87, p. 3227-3233, 2021.

Physiologically-based pharmacokinetics of ziprasidone in pregnant women.

British Journal of Clinical Pharmacology, v. 1, p. 10, 2019.

Reduced bioavailability of oral amoxicillin tablets compared to suspensions in RYGB bariatric subjects.

British Journal of Clinical Pharmacology, v. 85, p. 2118-2125, 2019.

Population pharmacokinetics of orally administrated bromopride: focus on the absorption process.

European Journal of Pharmaceutical Sciences, p. 105081, 2019.

Non-Procrustean pathways for complex generic drugs development.

Therapeutic Delivery, v. 9, p. 605-607, 2018.

Pharmacokinetic evaluation of avicularin using a model-based development approach.

Planta Medica, p. 373-381, 2015.

Simultaneous characterization of intravenous and oral pharmacokinetics of lychnopholide in rats by transit compartment model.

Planta Medica, p. 1121, 2015.

Characterization of intestinal absorption of C-glycoside flavonoid vicenin-2 from Lychnophora ericoides leafs in rats by nonlinear mixed effects modeling.

Revista Brasileira de Farmacognosia (Impresso), p. 1-10, 2015.

Introdução à farmacocinética.

In: Farmacologia e Terapêutica Clínica para a Equipe De Enfermagem. José Ricardo Chamhum de Almeida; Joice Mara Cruciol. (Org.). 10 ed. Porto Alegre: Atheneu, 2013.

Assessment of intestinal absorption of O-glycoside flavonoid avicularin using in situ single-pass intestinal perfusion technique.

Planta Medica, v. 78, p. PH18-PH18, 2012.

PK-PD modeling of β-lactam antibiotics: In vitro or in vivo models?.

Journal of Antibiotics, v. 64, p. 439-446, 2011.

Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis.

Analytical and Bioanalytical Chemistry, v. 391, p. 625-632, 2008.

Permeability profile estimation of flavonoids and other phenolic compounds by biopartitioning micellar capillary chromatography.

Journal of Agricultural and Food Chemistry, v. 55, p. 8372-8379, 2007.

Planejamento de
Experimentos (DoE)

Design of Nanostructured Lipid Carriers Containing Cymbopogon martinii (Palmarosa) Essential Oil against Aspergillus nomius.

Molecules, v. 26, p. 4825, 2021.

Development study of pectin/Surelease® solid microparticles for the delivery of L-alanyl-L-glutamine dipeptide.

Food Hydrocolloids, v. 89, p. 921-932, 2019.

A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes.

European Journal of Pharmaceutics and Biopharmaceutics, v. 143, p. 44-50, 2019.

Design and characterization of mucoadhesive gelatin-ethylcellulose microparticles for the delivery of curcumin to the bladder.

Current Drug Delivery, v. 15, p. 1-12, 2018.

<span data-metadata=""><span data-buffer="">Design of composite microparticle systems based on pectin and waste material of propolis for modified L-alanyl-L-glutamine release and with immunostimulant activity.

Pharmaceutical Development and Technology, v. 24, p. 1-12, 2017.

Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy.

Photodiagnosis and Photodynamic Therapy, v. 19, p. 284-297, 2017.

Response surface method optimization of a novel Hypericin formulation in P123 micelles for colorectal cancer and antimicrobial photodynamic therapy.

Journal of Photochemistry and Photobiology B-Biology, v. 170, p. 247-255, 2017.

Screening and In Vitro Evaluation of Mucoadhesive Thermoresponsive System Containing Methylene Blue for Local Photodynamic Therapy of Colorectal Cancer.

Pharmaceutical Research, v. 33, p. 776-791, 2016.

Nanocarriers for photodynamic therapy – rational formulation design and medium-scale manufacture.

International Journal of Pharmaceutics, v. 491, p. 250-260, 2015.

Contribuições para a comunidade científica

Farmacocinética, Modelagem & Simulação

Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report.

Editorial: Advanced approaches in pediatric clinical pharmacology

Experiences and initiatives on pharmacokinetic modeling and simulation data analysis: Perspectives from the Brazilian Health Regulatory Agency (ANVISA)

PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia.

Adult and pediatric physiologically based biopharmaceutics model to explain lamotrigine immediate release dissolution and absorption process.

Farmacometria Aplicada ao Desenvolvimento de Medicamentos.

Model-informed drug development of gastroretentive release systems for sildenafil citrate.

PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia.

Exploring in vitro solubility of lamotrigine in physiologically mimetic conditions to prospect the in vivo dissolution in pediatric population.

Nanomedicine Ex Machina: Between Model-Informed Development and Artificial Intelligence.

Biopredictive tools for the development of injectable drug products.

Pharmacokinetics of amoxicillin in obese and nonobese subjects.

Physiologically-based pharmacokinetics of ziprasidone in pregnant women.

Reduced bioavailability of oral amoxicillin tablets compared to suspensions in RYGB bariatric subjects.

Population pharmacokinetics of orally administrated bromopride: focus on the absorption process.

Non-Procrustean pathways for complex generic drugs development.

Pharmacokinetic evaluation of avicularin using a model-based development approach.

Simultaneous characterization of intravenous and oral pharmacokinetics of lychnopholide in rats by transit compartment model.

Characterization of intestinal absorption of C-glycoside flavonoid vicenin-2 from Lychnophora ericoides leafs in rats by nonlinear mixed effects modeling.

Introdução à farmacocinética.

Assessment of intestinal absorption of O-glycoside flavonoid avicularin using in situ single-pass intestinal perfusion technique.

PK-PD modeling of β-lactam antibiotics: In vitro or in vivo models?.

Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis.

Permeability profile estimation of flavonoids and other phenolic compounds by biopartitioning micellar capillary chromatography.

Planejamento de Experimentos (DoE)

Design of Nanostructured Lipid Carriers Containing Cymbopogon martinii (Palmarosa) Essential Oil against Aspergillus nomius.

Development study of pectin/Surelease® solid microparticles for the delivery of L-alanyl-L-glutamine dipeptide.

A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes.

Design and characterization of mucoadhesive gelatin-ethylcellulose microparticles for the delivery of curcumin to the bladder.

<span data-metadata=""><span data-buffer="">Design of composite microparticle systems based on pectin and waste material of propolis for modified L-alanyl-L-glutamine release and with immunostimulant activity.

Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy.

Response surface method optimization of a novel Hypericin formulation in P123 micelles for colorectal cancer and antimicrobial photodynamic therapy.

Screening and In Vitro Evaluation of Mucoadhesive Thermoresponsive System Containing Methylene Blue for Local Photodynamic Therapy of Colorectal Cancer.

Nanocarriers for photodynamic therapy – rational formulation design and medium-scale manufacture.

Contribuições
para a comunidade
científica

Farmacocinética,
Modelagem & Simulação

Planejamento de
Experimentos (DoE)